Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 6/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909662 | 0.85 | DHODH (0.45) | CDC7DBF4MAPTKDM4EDHODH | |
| SCHEMBL5909583 | 0.85 | DHODH (0.45) | CDC7DBF4MAPTKDM4EDHODH | |
| SCHEMBL6189633 | 0.83 | CDC7 (0.52) | CNR1CNR2CDC7DBF4MAPT | |
| SCHEMBL1250865 | 0.81 | CDC7 (0.58) | CNR1CNR2CDC7DBF4MAPT | |
| SCHEMBL5034238 | 0.79 | CDC7 (0.60) | CNR1CNR2CDC7DBF4MAPT | |
| SCHEMBL4477519 | 0.79 | CNR1 (0.57) | CNR1CNR2CDC7DBF4MAPT | |
| SCHEMBL6187754 | 0.78 | SMN1; SMN2 (0.37) | CNR2MAPTKDM4EPTGS2LMNA | |
| SCHEMBL6187166 | 0.78 | SMN1; SMN2 (0.39) | CNR2MAPTKDM4EPTGS2LMNA | |
| SCHEMBL2120730 | 0.77 | CDC7 (0.53) | CNR1CNR2CDC7DBF4MAPT | |
| SCHEMBL5036754 | 0.77 | CDC7 (0.58) | CNR1CNR2CDC7DBF4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581214-A1 | 4,5-DIARYLTHIAZOLE DERIVATIVES AS CB-1 LIGANDS | Astrazeneca AB (SE) | 2005-10-05 | — | — | EP | claimed |
| WO-2004058255-A1 | 4, 5-DIARYLTHIAZOLE DERIVATIVES AS CB-1 LIGANDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | claimed |