Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 4/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 4/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036754 | 0.93 | CDC7 (0.58) | CDC7DBF4CNR1CNR2KDM4E | |
| SCHEMBL1250865 | 0.92 | CDC7 (0.58) | CDC7DBF4CNR1CNR2KDM4E | |
| SCHEMBL2120730 | 0.90 | CDC7 (0.53) | CDC7DBF4CNR1CNR2KDM4E | |
| SCHEMBL5034238 | 0.89 | CDC7 (0.60) | CDC7DBF4CNR1CNR2KDM4E | |
| SCHEMBL5909592 | 0.86 | PTGS2 (0.59) | CDC7DBF4KDM4EMAPTDHODH | |
| SCHEMBL4477519 | 0.85 | CNR1 (0.57) | CDC7DBF4CNR1CNR2KDM4E | |
| SCHEMBL6205733 | 0.83 | CNR1 (0.41) | CDC7DBF4CNR1CNR2KDM4E | |
| SCHEMBL5909547 | 0.82 | PTGS2 (0.64) | CDC7DBF4KDM4EMAPTDHODH | |
| SCHEMBL5909558 | 0.80 | PTGS2 (0.59) | CDC7DBF4KDM4EMAPTDHODH | |
| SCHEMBL5034224 | 0.80 | CNR1 (0.57) | CDC7DBF4CNR1CNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581214-A1 | 4,5-DIARYLTHIAZOLE DERIVATIVES AS CB-1 LIGANDS | Astrazeneca AB (SE) | 2005-10-05 | — | — | EP | claimed |
| WO-2004058255-A1 | 4, 5-DIARYLTHIAZOLE DERIVATIVES AS CB-1 LIGANDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | claimed |