Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11172110 | 0.85 | CTBP2 (0.62) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3022221 | 0.80 | CTBP2 (0.57) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL20944776 | 0.79 | CTBP2 (0.51) | CTBP2ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL11178925 | 0.79 | CTBP2 (0.56) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7144102 | 0.79 | CTBP2 (0.56) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL24831479 | 0.79 | HTR3E (0.58) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4288608 | 0.79 | CTBP2 (0.56) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2079425 | 0.78 | NPC1 (0.46) | CTBP2PIK3CAALDH1A1KMT2AMEN1 | |
| SCHEMBL1582412 | 0.77 | CES1 (0.54) | CTBP2ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL27834585 | 0.77 | CTBP2 (0.58) | CTBP2HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581535-A1 | PYRROLOPYRIDAZINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004063197-A1 | PYRROLOPYRIDAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |