SCHEMBL6205849

SCHEMBL6205849

Nc1cc(Cl)ccc1CN1CCC(C(N)C(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)CC1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 19/20 0.62
SOS1 Q07889 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27580117 0.85 CCR2 (0.68) CCR2
SCHEMBL4844890 0.84 CCR2 (0.84) CCR2
SCHEMBL8218143 0.81 CCR2 (0.91) CCR2
SCHEMBL8218145 0.81 CCR2 (0.91) CCR2
SCHEMBL28747143 0.81 CCR2 (0.53) CCR2
SCHEMBL4840806 0.79 CCR2 (0.54) CCR2
SCHEMBL4846704 0.78 CCR2 (0.66) CCR2
SCHEMBL27532203 0.77 CCR2 (0.54) CCR2
SCHEMBL4841176 0.77 CCR2 (0.57) CCR2
SCHEMBL4842670 0.77 CCR2 (0.69) CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1553085-A1 Cyclic amine derivatives and their use as drugs TEIJIN LIMITED (JP) 2005-07-13 EP claimed
EP-1535909-A2 Cyclic amine derivatives and their use as drugs TEIJIN LIMITED (JP) 2005-06-01 EP claimed
CN-1384743-A Remedies or preventives for diseases in association with chemokines TEIJIN LTD (JP) 2002-12-11 CN disclosed
EP-1179341-A1 REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES TEIJIN LIMITED (JP) 2002-02-13 EP disclosed