Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27397034 | 0.87 | EPHX1 (0.57) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL27397033 | 0.87 | EPHX1 (0.57) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL13817895 | 0.82 | CSNK1E (0.60) | EPHX1HTR2AHRH1ANPEPSIGMAR1 | |
| SCHEMBL18034347 | 0.81 | EPHX1 (0.80) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL902633 | 0.81 | EPHX1 (0.80) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL2736189 | 0.81 | EPHX1 (0.80) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL902607 | 0.81 | EPHX1 (0.80) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL15476621 | 0.81 | EPHX1 (0.80) | EPHX1ANPEPSIGMAR1TAAR1SLC6A2 | |
| SCHEMBL28163396 | 0.80 | SIGMAR1 (0.58) | HTR2AHRH1SIGMAR1TAAR1SLC6A2 | |
| SCHEMBL172932 | 0.80 | EPHX1 (0.64) | EPHX1HTR2AHRH1ANPEPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071577-A1 | THIENOPYRIMIDINES AS MKNK1 AND MKNK2 INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015074986-A1 | THIENOPYRIMIDINES AS MKNK1 AND MKNK2 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-28 | — | — | WO | disclosed |
| EP-1505968-A1 | MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097047-A1 | MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2003-11-27 | — | — | WO | disclosed |