Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.41 |
| ▸ | FABP7 | O15540 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3785639 | 0.91 | KMT2A (0.44) | PRMT5WDR77TSHRKMT2AFABP5 | |
| SCHEMBL30564450 | 0.91 | KMT2A (0.44) | PRMT5WDR77TSHRKMT2AFABP5 | |
| SCHEMBL3789075 | 0.91 | KMT2A (0.44) | PRMT5WDR77TSHRKMT2AFABP5 | |
| SCHEMBL30951907 | 0.91 | KMT2A (0.44) | PRMT5WDR77TSHRKMT2AFABP5 | |
| SCHEMBL30824716 | 0.87 | TSHR (0.50) | TSHRKMT2AFABP5FABP7EPHX2 | |
| SCHEMBL8222797 | 0.87 | TSHR (0.50) | TSHRKMT2AFABP5FABP7EPHX2 | |
| SCHEMBL30555288 | 0.87 | TSHR (0.50) | TSHRKMT2AFABP5FABP7EPHX2 | |
| SCHEMBL31220527 | 0.85 | TSHR (0.52) | PRMT5WDR77TSHRKMT2AFABP5 | |
| SCHEMBL30276687 | 0.85 | TSHR (0.52) | PRMT5WDR77TSHRKMT2AFABP5 | |
| SCHEMBL711979 | 0.85 | TSHR (0.52) | PRMT5WDR77TSHRKMT2AFABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401453-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1401453-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002092563-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-11-21 | — | — | WO | disclosed |