Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TARDBP | Q13148 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2258293 | 0.91 | SPHK1 (0.39) | SPHK1PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL26203437 | 0.81 | NPC1 (0.42) | SPHK1KMT2ATARDBP | |
| SCHEMBL27033223 | 0.79 | SPHK1 (0.46) | SPHK1PDE4AFFAR4KMT2A | |
| SCHEMBL24158596 | 0.79 | KDM4E (0.36) | SPHK1PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27539170 | 0.77 | SPHK1 (0.37) | SPHK1PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4374339 | 0.76 | SPHK1 (0.42) | SPHK1EPHX2 | |
| SCHEMBL578731 | 0.76 | SPHK1 (0.45) | SPHK1EPHX2 | |
| SCHEMBL27055139 | 0.75 | SPHK1 (0.46) | SPHK1EPHX2KMT2A | |
| SCHEMBL26307445 | 0.74 | FFAR4 (0.36) | EPHX2FFAR4 | |
| SCHEMBL9037091 | 0.72 | SPHK1 (0.42) | SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | claimed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | claimed |