Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.41 |
| ▸ | WNT3A | P56704 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29514911 | 0.88 | AKR1C3 (0.47) | ABCG2KDM4CMAOBALDH1A1CTNNB1 | |
| SCHEMBL7002428 | 0.88 | AKR1C3 (0.47) | ABCG2KDM4CMAOBALDH1A1CTNNB1 | |
| SCHEMBL29442138 | 0.86 | KDM4C (0.52) | ABCG2GSK3BKDM4CMAOBPOLB | |
| SCHEMBL340702 | 0.86 | KDM4C (0.52) | ABCG2GSK3BKDM4CMAOBPOLB | |
| SCHEMBL23079145 | 0.85 | GSK3B (0.42) | ABCG2GSK3BKDM4CMAOBPOLB | |
| SCHEMBL1720148 | 0.85 | PARP1 (0.54) | POLBMAPK1KDM4EALDH1A1LMNA | |
| SCHEMBL341608 | 0.85 | GSK3B (0.42) | ABCG2GSK3BKDM4CMAOBPOLB | |
| SCHEMBL340356 | 0.85 | KDM4E (0.44) | ABCG2GSK3BKDM4CMAOBKDM4E | |
| SCHEMBL29625406 | 0.85 | PARP1 (0.54) | POLBMAPK1KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9236405 | 0.85 | KDM4C (0.51) | ABCG2GSK3BKDM4CMAOBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1593683-A2 | Dihydro-2,3-Benzodiazepine derivatives | ELI LILLY AND COMPANY (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1157992-B1 | Dihydro-2,3-Benzodiazepine derivatives | LILLY CO ELI (US) | 2005-08-24 | — | — | EP | disclosed |
| EP-0699678-B1 | Crystalline form of dihydro-2,3-benzodiazepine derivative | LILLY CO ELI (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0771198-B1 | DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES | LILLY CO ELI (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6329364-B1 | COMPOUND WITH CRYSTAL STRUCTURE FOR TREATMENT OF NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-12-11 | — | — | US | disclosed |
| EP-1157992-A1 | Dihydro-2,3-Benzodiazepine derivatives | ELI LILLY AND COMPANY (US) | 2001-11-28 | — | — | EP | disclosed |
| CN-1073996-C | Crystalline form of dihydro-2,3-benzodiazepine derivative | LILLY CO ELI (US) | 2001-10-31 | — | — | CN | disclosed |
| CN-1073995-C | Physical form of dihydro-2,3-benzodiazepine derivative | LILLY CO ELI (US) | 2001-10-31 | — | — | CN | disclosed |
| US-6288057-B1 | AMPA ANTAGONIST; NERVOUS SYSTEM, BRAIN, AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-0699676-B1 | Physical form of dihidro-2,3-benzodiazepine derivative | LILLY CO ELI (US) | 2001-02-07 | — | — | EP | disclosed |
| US-5795886-A | ANTICONVULSANTS | ELI LILLY AND COMPANY (US) | 1998-08-18 | — | — | US | disclosed |
| CN-1128264-A | Crystalline form of dihydro-2,3-benzodiazepine derivative | LILLY CO ELI (US) | 1996-08-07 | — | — | CN | disclosed |
| CN-1122338-A | Physical form of dihydro-2,3-benzodiazepine derivative | LILLY CO ELI (US) | 1996-05-15 | — | — | CN | disclosed |
| WO-1996006606-A1 | DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-03-07 | — | — | WO | disclosed |
| EP-0699678-A1 | Crystalline form of dihydro-2,3-benzodiazepine derivative | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |
| EP-0699676-A1 | Physical form of dihidro-2,3-benzodiazepine derivative | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |