SCHEMBL7002428

SCHEMBL7002428

O=C(c1ccccc1)c1cccc2c1OCO2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.47
CTNNB1 P35222 2/20 0.45
WNT3A P56704 2/20 0.45
GAA P10253 2/20 0.44
MAPT P10636 2/20 0.44
KDM4C Q9H3R0 1/20 0.42
ALDH1A1 P00352 2/20 0.42
ABCG2 Q9UNQ0 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
SRD5A2 P31213 1/20 0.41
ATM Q13315 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MAOB P27338 1/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C8 P10632 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29514911 1.00 AKR1C3 (0.47) AKR1C3CTNNB1WNT3AGAAMAPT
SCHEMBL6206600 0.88 ABCG2 (0.44) CTNNB1WNT3AGAAKDM4CALDH1A1
SCHEMBL27343882 0.87 CTNNB1 (0.53) AKR1C3CTNNB1WNT3AGAAMAPT
SCHEMBL29442138 0.82 KDM4C (0.52) CTNNB1WNT3AKDM4CALDH1A1ABCG2
SCHEMBL340702 0.82 KDM4C (0.52) CTNNB1WNT3AKDM4CALDH1A1ABCG2
Hydrochloric Acid SCHEMBL9236405 0.81 KDM4C (0.51) CTNNB1WNT3AKDM4CALDH1A1ABCG2
Biphenyl SCHEMBL27726506 0.80 KDM4C (0.48) KDM4CALDH1A1ABCG2SMN1; SMN2ATM
SCHEMBL30456847 0.79 MAOB (0.42) CTNNB1WNT3AGAAKDM4CALDH1A1
SCHEMBL27909830 0.79 AKR1C3 (0.53) AKR1C3GAAMAPTALDH1A1SMN1; SMN2
SCHEMBL23079145 0.77 GSK3B (0.42) CTNNB1WNT3AGAAKDM4CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066039-A4 SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF COCENSYS INC (US) 2003-02-26 EP disclosed
EP-1066039-A1 SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF Cocensys, Inc. (US) 2001-01-10 EP disclosed
WO-1999044612-A1 SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF COCENSYS, INC. (US) 1999-09-10 WO disclosed
WO-1996040646-A1 DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS SYMPHONY PHARMACEUTICALS, INC. (US) 1996-12-19 WO disclosed
US-4169089-A PHOTOSTABILIZERS FOR POLYMERS ARGUS CHEMICAL CORPORATION (US) 1979-09-25 US disclosed