Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211656 | 0.84 | CTNNB1 (0.68) | PARP10CTNNB1LMNAMAPTKMT2A | |
| SCHEMBL3692982 | 0.83 | PARP10 (0.53) | PARP10PARP3CTNNB1LMNAOPRK1 | |
| SCHEMBL2562259 | 0.83 | CTNNB1 (0.70) | PARP10PARP3CTNNB1LMNAMAPT | |
| SCHEMBL3691763 | 0.81 | PARP10 (0.53) | PARP10PARP3CTNNB1LMNAKMT2A | |
| SCHEMBL3697986 | 0.78 | PARP10 (0.50) | PARP10PARP3CTNNB1LMNAMAPT | |
| SCHEMBL1135994 | 0.76 | CTSD (0.49) | LMNAMAPTKMT2AMEN1NR1I2 | |
| SCHEMBL16829425 | 0.75 | MEN1 (0.49) | LMNAMAPTKMT2AMEN1NR1I2 | |
| SCHEMBL3697056 | 0.75 | PARP10 (0.53) | PARP10PARP3CTNNB1LMNAMAPT | |
| SCHEMBL15334095 | 0.74 | KMT2A (0.42) | CTNNB1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL13599494 | 0.74 | CTNNB1 (0.47) | PARP10PARP3CTNNB1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562595-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004026305-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |