Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 9/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489553 | 1.00 | MEN1 (0.43) | MEN1GAAKMT2ASHMT2KDM4E | |
| SCHEMBL6206334 | 0.84 | MEN1 (0.46) | MEN1GAAKMT2AMAPTSTK17B | |
| SCHEMBL3620326 | 0.79 | NPC1 (0.40) | SHMT2MAPTFAAHDAGLA | |
| SCHEMBL7723226 | 0.78 | MAPT (0.38) | MEN1KMT2AMAPTCYP3A4FAAH | |
| SCHEMBL5947648 | 0.78 | NPC1 (0.41) | MEN1GAAKMT2ASHMT2KDM4E | |
| SCHEMBL5947645 | 0.78 | NPC1 (0.41) | MEN1GAAKMT2ASHMT2KDM4E | |
| SCHEMBL3627060 | 0.77 | FAAH (0.40) | SHMT2MAPTFAAHDAGLA | |
| SCHEMBL3622704 | 0.77 | FAAH (0.40) | SHMT2MAPTFAAHDAGLA | |
| SCHEMBL13504879 | 0.77 | FAAH (0.40) | SHMT2MAPTFAAHDAGLA | |
| SCHEMBL3622701 | 0.77 | FAAH (0.40) | SHMT2MAPTFAAHDAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | disclosed |