Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204974 | 0.89 | POLB (0.64) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6205058 | 0.85 | POLB (0.62) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6207474 | 0.84 | KMT2A (0.53) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206450 | 0.84 | POLB (0.55) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206261 | 0.83 | ADORA2A (0.55) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6205974 | 0.82 | POLB (0.57) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6205212 | 0.82 | POLB (0.80) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6207376 | 0.82 | POLB (0.58) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6207018 | 0.82 | HPGD (0.68) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206629 | 0.82 | POLB (0.56) | POLBRAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |