Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633439 | 0.89 | TDP1 (0.69) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL5422035 | 0.83 | TDP1 (0.73) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL8599281 | 0.81 | TDP1 (0.77) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL6488590 | 0.81 | TDP1 (0.61) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL11878394 | 0.81 | TDP1 (0.58) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL11617258 | 0.79 | TDP1 (0.55) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL3194897 | 0.79 | TDP1 (0.54) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL7068671 | 0.78 | TDP1 (0.95) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL1052631 | 0.78 | TDP1 (0.86) | TDP1MAPTLMNAL3MBTL1HDAC1 | |
| SCHEMBL5214695 | 0.78 | TDP1 (0.64) | TDP1MAPTLMNAL3MBTL1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581535-A1 | PYRROLOPYRIDAZINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004063197-A1 | PYRROLOPYRIDAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |