Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.53 |
| ▸ | FAAH | O00519 | 5/20 | 0.51 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050407 | 0.79 | CES1 (0.54) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL6808997 | 0.79 | CES1 (0.54) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL3304973 | 0.76 | FAAH (0.61) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL518554 | 0.76 | — | — | |
| SCHEMBL7371238 | 0.75 | FAAH (0.68) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL21645415 | 0.75 | CES1 (0.55) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL7444620 | 0.75 | FAAH (0.81) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL21645829 | 0.75 | FAAH (0.64) | CES1FAAHNCEH1HDAC3HDAC4 | |
| SCHEMBL4152892 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL6207350 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | disclosed |