Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 18/20 | 0.55 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.42 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208336 | 0.94 | KIF11 (0.48) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3962257 | 0.92 | KIF11 (0.65) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL6207965 | 0.89 | KIF11 (0.56) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3958081 | 0.88 | KIF11 (0.55) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3957538 | 0.88 | KIF11 (0.55) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3961161 | 0.85 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL6206668 | 0.82 | KIF11 (0.59) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4039730 | 0.82 | KIF11 (0.70) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL4035702 | 0.81 | KIF11 (0.69) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3961130 | 0.81 | KIF11 (0.53) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | claimed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | claimed |
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |