Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 9/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398384 | 0.95 | MAP2K1 (0.38) | MAP2K1MAP2K2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6403621 | 0.92 | MAP2K1 (0.39) | MAP2K1MAP2K2PIM1CAMK2BBRAF | |
| SCHEMBL6206940 | 0.92 | TGFBR1 (0.30) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6208372 | 0.91 | TSHR (0.35) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6400419 | 0.86 | KDM4E (0.38) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6400380 | 0.82 | FLT1 (0.32) | FLT1KDR | |
| SCHEMBL6206758 | 0.80 | MAP2K1 (0.43) | MAP2K1MAP2K2PIM1CAMK2BBRAF | |
| SCHEMBL6400824 | 0.79 | MAP2K1 (0.38) | MAP2K1MAP2K2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6403645 | 0.79 | MAP2K1 (0.42) | MAP2K1MAP2K2PIM1CAMK2BBRAF | |
| SCHEMBL6398380 | 0.76 | MAP2K1 (0.38) | MAP2K1MAP2K2CYP1A2CYP2D6PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | claimed |