Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1786969 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10GLA | |
| SCHEMBL3815180 | 0.89 | ALDH1A1 (0.53) | ALDH1A1HSD17B10GAAMAPTLMNA | |
| SCHEMBL4214562 | 0.89 | ALDH1A1 (0.53) | ALDH1A1HSD17B10GAAMAPTLMNA | |
| SCHEMBL3860431 | 0.89 | ALDH1A1 (0.53) | ALDH1A1HSD17B10GAAMAPTLMNA | |
| SCHEMBL3205373 | 0.84 | TSHR (0.49) | ALDH1A1KDM4EGLATSHRMAPT | |
| SCHEMBL5205180 | 0.84 | TSHR (0.49) | ALDH1A1KDM4EGLATSHRMAPT | |
| SCHEMBL3806023 | 0.84 | TSHR (0.49) | ALDH1A1KDM4EGLATSHRMAPT | |
| SCHEMBL3805744 | 0.84 | EPHX1 (0.47) | ALDH1A1HSD17B10GLATSHRMAPT | |
| SCHEMBL3222025 | 0.82 | TSHR (0.46) | ALDH1A1KDM4EHSD17B10GLAGAA | |
| SCHEMBL1951762 | 0.82 | TSHR (0.46) | ALDH1A1KDM4EHSD17B10GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005295-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |