Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 11/20 | 0.52 |
| ▸ | CES1 | P23141 | 11/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207030 | 1.00 | CES2 (0.52) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6207035 | 0.83 | CES2 (0.52) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6207820 | 0.78 | CES2 (0.56) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6207823 | 0.78 | CES2 (0.56) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL29664603 | 0.76 | CES2 (0.59) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6207028 | 0.75 | CES2 (0.52) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6206771 | 0.75 | CES2 (0.52) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6205110 | 0.75 | CES2 (0.56) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6205114 | 0.75 | CES2 (0.56) | CES2CES1TSHRL3MBTL1CYP2C19 | |
| SCHEMBL6206777 | 0.75 | CES2 (0.52) | CES2CES1TSHRL3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |