Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.37 |
| ▸ | NPY1R | P25929 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5826786 | 0.99 | CRHR1 (0.37) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL6209775 | 0.96 | CRHR1 (0.40) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL5826451 | 0.93 | NPY1R (0.42) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL5826819 | 0.91 | NPY1R (0.36) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL5826791 | 0.89 | CRHR1 (0.43) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL5827061 | 0.88 | NPY1R (0.40) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL5826651 | 0.87 | NPY1R (0.39) | CRHR1NPY1RKDM4EALDH1A1LMNA | |
| SCHEMBL5826550 | 0.85 | NPY1R (0.36) | CRHR1NPY1R | |
| SCHEMBL5826424 | 0.84 | CRHR1 (0.48) | CRHR1NPY1R | |
| SCHEMBL5827111 | 0.84 | NPY1R (0.36) | CRHR1NPY1RKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1238979-B1 | FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME | EISAI CO LTD (JP) | 2005-03-02 | — | — | EP | disclosed |
| EP-1408040-A1 | Tricyclic fused heterocyclic compounds as CRFantagonists | Eisai Co., Ltd. (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-1238979-A1 | FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-09-11 | — | — | EP | disclosed |