SCHEMBL6207124

SCHEMBL6207124

CCc1ccc(Nc2c(-c3nnc(NCCN4CCOCC4)o3)ccc(F)c2F)c(F)c1.CCc1ccc(Nc2c(-c3nnc(NCCOc4ccccc4)o3)ccc(F)c2F)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 9/20 0.42
KCNH2 Q12809 8/20 0.42
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
CHRNA1 P02708 1/20 0.40
CYP1A2 P05177 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
TRPC5 Q9UL62 1/20 0.39
MAP3K8 P41279 2/20 0.39
CSF1R P07333 1/20 0.37
TSHR P16473 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 2/20 0.35
MAPK14 Q16539 2/20 0.35
USP2 O75604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6399220 0.91 CHRNA7 (0.43) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL6227680 0.90 CHRNA7 (0.33) CHRNA7KCNH2CYP3A4CHRNA1CHRNB2
SCHEMBL6403620 0.87 CHRNA7 (0.48) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL6190172 0.82 CHRNA7 (0.44) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL6189562 0.82 CHRNA7 (0.44) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL15598681 0.82 CHRNA7 (0.44) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL6190835 0.81 CHRNA7 (0.45) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL6207914 0.80 CHRNA7 (0.51) CHRNA7KCNH2CYP3A4CHRNA1CHRNB2
SCHEMBL29371646 0.80 MAP2K2 (0.47) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19
SCHEMBL6207045 0.80 MAP2K2 (0.47) CHRNA7KCNH2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1578736-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES Warner-Lambert Company LLC (US) 2005-09-28 EP claimed
WO-2004056789-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES WARNER-LAMBERT COMPANY LLC (US) 2004-07-08 WO claimed