Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | FABP3 | P05413 | 3/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.46 |
| ▸ | FABP7 | O15540 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507667 | 0.83 | ESR1 (0.58) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL5169415 | 0.83 | ESR1 (0.58) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL29733244 | 0.80 | FABP3 (0.49) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL4389213 | 0.80 | FABP3 (0.49) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL35121 | 0.80 | FABP3 (0.49) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL27559161 | 0.79 | BACE1 (0.58) | KDM4EHPGDHSD17B10FABP3FABP5 | |
| Biphenyl SCHEMBL27827806 | 0.79 | FABP3 (0.48) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL4102451 | 0.78 | KDM4E (0.43) | KDM4EHPGDMAPTHSD17B10FABP3 | |
| SCHEMBL236823 | 0.77 | FABP3 (0.53) | KDM4EFABP3FABP5FABP7TDP1 | |
| SCHEMBL236822 | 0.77 | FABP3 (0.53) | KDM4EHPGDHSD17B10FABP3FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546134-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014895-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |