Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205011 | 0.85 | FLT3 (0.48) | MAPK1FLT3TTBK1PAK1HTT | |
| SCHEMBL2343403 | 0.78 | MAPK1 (0.58) | MAPK1FLT3NPC1JAK2RAB9A | |
| SCHEMBL26785933 | 0.77 | MAPK1 (0.69) | MAPK1FLT3TTBK1MKNK1EGFR | |
| SCHEMBL26784629 | 0.76 | MAPK1 (0.71) | MAPK1FLT3TTBK1HTTMKNK1 | |
| SCHEMBL4693022 | 0.70 | FLT3 (0.66) | MAPK1FLT3TTBK1HTTMKNK1 | |
| SCHEMBL6844684 | 0.69 | ALDH1A1 (0.48) | MAPK1FLT3BRAFAURKBMAPK14 | |
| SCHEMBL4686916 | 0.67 | PAK1 (0.64) | MAPK1FLT3NPC1RAB9ATTBK1 | |
| SCHEMBL31686015 | 0.67 | KCNK3 (0.71) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL1406620 | 0.67 | MAPK1 (1.00) | MAPK1FLT3TTBK1HTTMKNK1 | |
| SCHEMBL8342652 | 0.66 | MAPT (0.64) | NPC1RAB9AHTTMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |