Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 3/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 11/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207282 | 0.90 | MAP3K8 (0.46) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL15598681 | 0.87 | CHRNA7 (0.44) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL6399220 | 0.85 | CHRNA7 (0.43) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL6207045 | 0.85 | MAP2K2 (0.47) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL29371646 | 0.85 | MAP2K2 (0.47) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL6207193 | 0.85 | MAP2K1 (0.35) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6189558 | 0.83 | CHRNA7 (0.51) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL6206316 | 0.83 | CHRNA7 (0.43) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL6206530 | 0.83 | CHRNA7 (0.43) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 | |
| SCHEMBL6189562 | 0.82 | CHRNA7 (0.44) | MAP3K8CHRNA7KCNH2CHRNA1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | MAPK1, MAP3K1, MAPK3 | MAP3K8 18/4885CHRNA7 4667/4885KCNH2 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.