Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.64 |
| ▸ | CDK4 | P11802 | 7/20 | 0.58 |
| ▸ | PLK1 | P53350 | 3/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 5/20 | 0.58 |
| ▸ | CDK9 | P50750 | 5/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.58 |
| ▸ | CDK7 | P50613 | 4/20 | 0.58 |
| ▸ | CDK1 | P06493 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | WEE1 | P30291 | 3/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804658 | 0.92 | CDK2 (0.64) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL2073788 | 0.90 | CDK2 (0.62) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL6156585 | 0.84 | CDK2 (0.71) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL6209767 | 0.83 | CDK2 (0.76) | CDK2CDK4CCNA2AURKACDK9 | |
| SCHEMBL2285645 | 0.82 | CDK2 (0.78) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL2075966 | 0.82 | CDK2 (0.65) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL2074524 | 0.82 | CDK2 (0.57) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL4797854 | 0.81 | CDK2 (0.67) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL2073696 | 0.81 | CDK2 (0.61) | CDK2CDK4PLK1CCNA2AURKA | |
| SCHEMBL4803422 | 0.80 | CDK2 (0.65) | CDK2CDK4PLK1CCNA2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567522-A1 | PYRIMIDINE COMPOUNDS | Cyclacel Limited (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004043953-A1 | PYRIMIDINE COMPOUNDS | CYCLACEL LIMITED (GB) | 2004-05-27 | — | — | WO | disclosed |