Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.76 |
| ▸ | CDK9 | P50750 | 11/20 | 0.76 |
| ▸ | AURKA | O14965 | 10/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.76 |
| ▸ | CDK4 | P11802 | 9/20 | 0.76 |
| ▸ | CDK1 | P06493 | 5/20 | 0.74 |
| ▸ | WEE1 | P30291 | 5/20 | 0.67 |
| ▸ | JAK2 | O60674 | 5/20 | 0.67 |
| ▸ | FLT3 | P36888 | 4/20 | 0.67 |
| ▸ | JAK3 | P52333 | 4/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.67 |
| ▸ | PAK4 | O96013 | 3/20 | 0.67 |
| ▸ | ABL1 | P00519 | 3/20 | 0.67 |
| ▸ | FYN | P06241 | 3/20 | 0.67 |
| ▸ | CSF1R | P07333 | 3/20 | 0.67 |
| ▸ | RET | P07949 | 3/20 | 0.67 |
| ▸ | MET | P08581 | 3/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841556 | 0.91 | CDK2 (0.71) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL2075354 | 0.91 | CDK2 (0.70) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL16366078 | 0.87 | CDK2 (0.65) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL2076207 | 0.86 | CDK2 (1.00) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL16324470 | 0.86 | CDK2 (0.64) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL16366480 | 0.86 | CDK2 (0.64) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL2075969 | 0.85 | CDK2 (1.00) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL4157096 | 0.83 | CDK2 (0.82) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL4152059 | 0.83 | CDK2 (0.82) | CDK2CDK9AURKAAURKBCDK4 | |
| SCHEMBL6208539 | 0.83 | CDK2 (0.64) | CDK2CDK9AURKAAURKBCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567522-A1 | PYRIMIDINE COMPOUNDS | Cyclacel Limited (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004043953-A1 | PYRIMIDINE COMPOUNDS | CYCLACEL LIMITED (GB) | 2004-05-27 | — | — | WO | disclosed |