Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857314 | 0.83 | MAP2 (0.45) | KDM4EEGFRSRCNR4A2TDP1 | |
| SCHEMBL5705595 | 0.77 | NR4A2 (0.67) | KDM4ENR4A2KMT2ALMNARAB9A | |
| SCHEMBL28584430 | 0.77 | KDM4E (0.60) | KDM4EEGFRSRCNR4A2TDP1 | |
| SCHEMBL6487558 | 0.75 | KDM4E (0.63) | KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL8504135 | 0.75 | NR4A2 (0.68) | KDM4EEGFRSRCNR4A2TDP1 | |
| SCHEMBL2929140 | 0.74 | AHR (0.55) | KDM4EKMT2ALMNARAB9AALDH1A1 | |
| SCHEMBL2339411 | 0.74 | KDM4E (0.66) | KDM4ENR4A2TDP1KMT2AALDH1A1 | |
| SCHEMBL29955046 | 0.74 | KDM4E (0.66) | KDM4ENR4A2TDP1KMT2AALDH1A1 | |
| SCHEMBL26963262 | 0.72 | KDM4E (0.55) | KDM4EEGFRSRCNR4A2TDP1 | |
| SCHEMBL13062894 | 0.72 | KDM4E (0.55) | KDM4EEGFRSRCNR4A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556349-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS 11-BETAHSD1 INHIBITORS | Astrazeneca AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004033427-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS 11-BETAHSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2004-04-22 | — | — | WO | disclosed |