Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.59 |
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212880 | 1.00 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6210662 | 0.98 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6371065 | 0.98 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6209611 | 0.82 | ADAM17 (0.56) | ADAM17MMP13 | |
| SCHEMBL6209862 | 0.81 | ADAM17 (0.63) | ADAM17MMP13MMP2MMP9 | |
| SCHEMBL6209502 | 0.81 | ADAM17 (0.64) | ADAM17MMP13MMP2 | |
| SCHEMBL6210993 | 0.80 | ADAM17 (0.54) | ADAM17 | |
| SCHEMBL6209088 | 0.79 | ADAM17 (0.60) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7057241 | 0.78 | ADAM17 (0.76) | ADAM17MMP13 | |
| SCHEMBL6364792 | 0.78 | ADAM17 (0.61) | ADAM17MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539740-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024715-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |