Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 12/20 | 0.39 |
| ▸ | STK17B | O94768 | 9/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214422 | 0.96 | KDM4E (0.40) | PTK2STK17ASOS1KDM4EALDH1A1 | |
| SCHEMBL6210266 | 0.96 | PTK2 (0.43) | PTK2STK17ASTK17BKDM4EALDH1A1 | |
| SCHEMBL6209610 | 0.89 | PTK2 (0.52) | PTK2KDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL6212755 | 0.89 | PTK2 (0.46) | PTK2SOS1KDM4EALDH1A1MAPT | |
| SCHEMBL6829733 | 0.87 | PTK2 (0.43) | PTK2STK17AKDM4EALDH1A1MAPT | |
| SCHEMBL6214366 | 0.87 | PTK2 (0.43) | PTK2STK17ASTK17BKDM4EALDH1A1 | |
| SCHEMBL6209410 | 0.83 | IGF1R (0.48) | PTK2KDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL6215668 | 0.82 | GSK3B (0.38) | KDM4EALDH1A1MAPTDRD2ALOX15 | |
| SCHEMBL6832992 | 0.82 | GSK3B (0.38) | KDM4EALDH1A1MAPTDRD2ALOX15 | |
| SCHEMBL6274350 | 0.80 | PTK2 (0.52) | PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |