Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 6/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 7/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212755 | 0.91 | PTK2 (0.46) | PTK2PTK2BSYK | |
| SCHEMBL6829733 | 0.84 | PTK2 (0.43) | PTK2PTK2BPAK4 | |
| SCHEMBL6214422 | 0.84 | KDM4E (0.40) | PTK2PTK2BSYKPAK4 | |
| SCHEMBL6242870 | 0.82 | PTK2 (0.52) | PTK2PTK2B | |
| SCHEMBL6209610 | 0.82 | PTK2 (0.52) | PTK2PTK2BALK | |
| SCHEMBL6209584 | 0.80 | PTK2 (0.41) | PTK2 | |
| SCHEMBL6213528 | 0.80 | PTK2 (0.78) | PTK2PTK2BSYKPAK4ROCK2 | |
| SCHEMBL6241400 | 0.80 | PTK2 (0.75) | PTK2PTK2BWEE1ALKPAK4 | |
| SCHEMBL6210266 | 0.76 | PTK2 (0.43) | PTK2ALK | |
| SCHEMBL6214366 | 0.76 | PTK2 (0.43) | PTK2PTK2BPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |