Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211457 | 0.81 | CNR2 (0.42) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27642695 | 0.73 | GAA (0.52) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6207192 | 0.69 | MAPK14 (0.55) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27663237 | 0.69 | GAA (0.45) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27663169 | 0.69 | GAA (0.44) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31367847 | 0.68 | MAPK14 (0.74) | MEN1KMT2ASMN1; SMN2MAPK14RIPK2 | |
| SCHEMBL6208952 | 0.66 | MAPK14 (0.40) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL16600481 | 0.63 | NPC1 (0.56) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL457993 | 0.63 | NPC1 (0.84) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL23573548 | 0.63 | NPC1 (0.77) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093248-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-13 | — | — | WO | disclosed |