Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207192 | 0.84 | MAPK14 (0.55) | MAPK14MAP2K1GAAMEN1KMT2A | |
| SCHEMBL5118656 | 0.80 | MAPK14 (0.59) | MAPK14MAP2K1MAPK13 | |
| SCHEMBL3225734 | 0.73 | MAPK14 (0.44) | MAPK14MAP2K1CNR1CNR2KDR | |
| SCHEMBL27663169 | 0.71 | GAA (0.44) | MAPK14RIPK2GAAMEN1KMT2A | |
| SCHEMBL27663237 | 0.70 | GAA (0.45) | MAPK14RIPK2GAAMEN1KMT2A | |
| SCHEMBL27642695 | 0.70 | GAA (0.52) | MAPK14GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL3225729 | 0.69 | MAPK14 (0.43) | MAPK14MAP2K1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6189876 | 0.68 | MAPK14 (0.48) | MAPK14ALDH1A1SMN1; SMN2 | |
| SCHEMBL6209656 | 0.66 | GAA (0.43) | MAPK14RIPK2GAAMEN1KMT2A | |
| SCHEMBL31367847 | 0.64 | MAPK14 (0.74) | MAPK14RIPK2MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093248-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-13 | — | — | WO | disclosed |