Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 4/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834100 | 0.77 | MAPT (0.44) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL4834115 | 0.75 | MAPT (0.44) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL6209464 | 0.70 | GRIN1 (0.38) | MAPK14KDM4EMAPT | |
| SCHEMBL4839676 | 0.69 | MAPK14 (0.67) | MAPK14CYP3A4 | |
| SCHEMBL6210581 | 0.69 | BACE1 (0.31) | — | |
| SCHEMBL6210807 | 0.67 | MAPK14 (0.50) | MAPK14CYP3A4 | |
| SCHEMBL6256080 | 0.66 | KDM4E (0.53) | MAPK14CYP3A4KDM4E | |
| SCHEMBL6212371 | 0.66 | MAPK14 (0.44) | MAPK14CYP3A4KDM4E | |
| SCHEMBL6211780 | 0.66 | BRD4 (0.39) | MAPK14CYP3A4BRD4 | |
| SCHEMBL6213850 | 0.66 | PTGS2 (0.42) | MAPK14KDM4EMAPTATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |