Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425083 | 0.88 | ALDH1A1 (0.57) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL5465423 | 0.84 | PDGFRB (0.53) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL4992802 | 0.84 | ALDH1A1 (0.52) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL2435686 | 0.84 | ALDH1A1 (0.55) | ALDH1A1GAAGFERMAPTTSHR | |
| SCHEMBL3726108 | 0.82 | ALDH1A1 (0.47) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL2593349 | 0.82 | CYP1A2 (0.50) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL29902882 | 0.82 | TSHR (0.47) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL4131823 | 0.82 | ATM (0.47) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL4857085 | 0.81 | TDP1 (0.53) | ALDH1A1GAAMAPTLMNATSHR | |
| SCHEMBL4857095 | 0.81 | TDP1 (0.53) | ALDH1A1GAAMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1780821-A | Heterocyclic kinase inhibitors. | ABBOTT LAB (US) | 2006-05-31 | — | — | CN | disclosed |
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |