Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TYMP | P19971 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873114 | 0.79 | AKT2 (1.00) | AKT2CHEK1KMT2ABRD4L3MBTL1 | |
| SCHEMBL5865715 | 0.78 | AKT2 (0.68) | AKT2CHEK1KMT2ABRD4L3MBTL1 | |
| SCHEMBL8493201 | 0.77 | TDP1 (0.50) | KMT2ANPSR1NFKB1NFKB2RELA | |
| SCHEMBL11116234 | 0.76 | AKT2 (0.66) | AKT2CHEK1KMT2ABRD4L3MBTL1 | |
| SCHEMBL27260360 | 0.76 | AKT2 (0.66) | AKT2CHEK1KMT2ATYMPBRD4 | |
| SCHEMBL4749775 | 0.76 | AKT2 (0.66) | AKT2CHEK1KMT2ABRD4L3MBTL1 | |
| SCHEMBL1057636 | 0.76 | AKT2 (0.66) | AKT2CHEK1KMT2ABRD4L3MBTL1 | |
| SCHEMBL6209399 | 0.76 | AKT2 (0.42) | AKT2CHEK1KMT2ATYMPL3MBTL1 | |
| SCHEMBL17637927 | 0.74 | AKT2 (0.63) | AKT2CHEK1KMT2ATYMPL3MBTL1 | |
| SCHEMBL10131903 | 0.73 | AKT2 (0.61) | AKT2CHEK1KMT2AL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |