Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 2/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842957 | 0.84 | SMN1; SMN2 (0.47) | AKT2CHEK1KMT2ANFKB1NFKB2 | |
| SCHEMBL1248139 | 0.81 | IKBKB (0.59) | AKT2CHEK1KMT2AMAPK1NPSR1 | |
| SCHEMBL13310491 | 0.81 | IKBKB (0.59) | AKT2CHEK1KMT2AMAPK1GSK3B | |
| SCHEMBL758310 | 0.81 | MAPK14 (0.45) | AKT2CHEK1KMT2AGSK3AGSK3B | |
| SCHEMBL11437179 | 0.80 | AKT2 (0.44) | AKT2CHEK1KMT2ANFKB1NFKB2 | |
| SCHEMBL873114 | 0.79 | AKT2 (1.00) | AKT2CHEK1KMT2AMAPK1NPSR1 | |
| SCHEMBL10166769 | 0.79 | MAPK1 (0.68) | AKT2CHEK1KMT2ANFKB1NFKB2 | |
| SCHEMBL19256221 | 0.78 | AKT2 (0.58) | AKT2CHEK1KMT2ANFKB1NFKB2 | |
| SCHEMBL13516427 | 0.78 | MAPT (0.50) | KMT2AMAPK1DYRK1AMAPTSMN1; SMN2 | |
| SCHEMBL27926884 | 0.78 | AKT2 (0.46) | AKT2CHEK1KMT2ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343338-C | Yellow anionic disazo dyes | CIBA SC HOLDING AG (CH) | 2007-10-17 | — | — | CN | claimed |
| CN-1659239-A | Yellow anionic disazo dyes | CIBA SC HOLDING AG (CH) | 2005-08-24 | — | — | CN | claimed |
| WO-2003064384-A2 | ENVIRONMENT FRIENDLY REAGENTS AND PROCESS FOR TRIFLUOROMETHYLSULFINYLATION OF ORGANIC COMPOUNDS | VIRBAC S.A. (FR) | 2003-08-07 | — | — | WO | claimed |
| US-20230124492-A1 | COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2023-04-20 | — | — | US | disclosed |
| CN-115666563-A | Compositions and methods of substituted 7- (piperazin-1-yl) pyrazolo [1,5-a ] pyrimidine analogs as KRAS inhibitors | 得克萨斯系统大学评议会 | 2023-01-31 | — | — | CN | disclosed |
| EP-4072548-A1 | COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS | The Board of Regents of The University of Texas System (US) | 2022-10-19 | — | — | EP | disclosed |
| WO-2021119343-A1 | COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-06-17 | — | — | WO | disclosed |
| US-20210163489-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | NYSNOBIO IRELAND DAC (IE) | 2021-06-03 | — | — | US | disclosed |
| US-20210163489-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | NYSNOBIO IRELAND DAC (IE) | 2021-06-03 | — | — | US | disclosed |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | BIOENERGENIX LLC (US) | 2021-03-23 | — | — | US | disclosed |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | BIOENERGENIX LLC (US) | 2021-03-23 | — | — | US | disclosed |
| WO-1998016514-A1 | ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |
| EP-0572450-A1 | AZO DYES HAVING A DIAZO COMPONENT FROM THE AMINOBENZOPHENONE SERIES, AS WELL AS BISULPHONATED PYRIDONE COMPOUNDS. | BASF AG (DE) | 1993-12-08 | — | — | EP | disclosed |
| EP-0169813-A2 | Photographic recording material for the silver dye-bleaching process | CIBA-GEIGY AG (CH) | 1986-01-29 | — | — | EP | disclosed |
| EP-0101664-A1 | Monoazo dyestuffs, their preparation and their use | CIBA-GEIGY AG (CH) | 1984-02-29 | — | — | EP | disclosed |
| EP-0101408-A1 | Monoazo dyestuffs, their preparation and their use | CIBA-GEIGY AG (CH) | 1984-02-22 | — | — | EP | disclosed |
| EP-0082117-A1 | Chromium complexes of polyazo dyestuffs | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | disclosed |
| EP-0056475-A2 | Pharmaceutical compositions | MERCK PATENT GmbH (DE) | 1982-07-28 | — | — | EP | disclosed |
| US-4113718-A | Basic azo dyes | CIBA-GEIGY CORPORATION (US) | 1978-09-12 | — | — | US | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230124492-A1 | COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS | KRAS, NRAS, TP53 | AKT2 74/4885CHEK1 48/4885KMT2A 3205/4885 |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | PASK, PDXK, PANK2 | AKT2 405/4885CHEK1 294/4885KMT2A 3661/4885 |
| US-20210163489-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | PINK1, ADRM1, LRRK2 | AKT2 413/4885CHEK1 657/4885KMT2A 2432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.