Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27760751 | 0.85 | KDM4E (0.40) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL6438423 | 0.84 | KDM4E (0.40) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL212954 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL5982033 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL3198393 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL10512942 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL1772589 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL14321592 | 0.75 | ALOX5 (0.44) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL10597711 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL5794328 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1HPGDPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023094734-A1 | LIGANDS SPECIFICALLY TARGETING VESICULAR GLUTAMATE TRANSPORTERS FOR SUPER-RESOLUTION IMAGING | Sorbonne Université (FR) | 2023-06-01 | — | — | WO | disclosed |
| EP-1509217-A1 | MONOTHERAPY FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH CYCLOOXYGENASE-2 (COX 2) INHIBITOR(S) | Pharmacia Corporation (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101441-A1 | MONOTHERAPY FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH CYCLOOXYGENASE-2 (COX 2) INHIBITOR(S) | PHARMACIA CORPORATION (US) | 2003-12-11 | — | — | WO | disclosed |
| EP-0977748-A1 | SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047890-A1 | SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-10-29 | — | — | WO | disclosed |