Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757083 | 0.95 | PDE10A (0.49) | PDE10ATP53LMNAMAPTKMT2A | |
| SCHEMBL5759073 | 0.93 | TP53 (0.49) | PDE10ARXFP1TP53LMNAMAPT | |
| SCHEMBL5756461 | 0.88 | PDE10A (0.48) | PDE10ARXFP1TP53LMNAMAPT | |
| SCHEMBL5759410 | 0.86 | PDE10A (0.48) | PDE10ATP53LMNAKMT2AKLKB1 | |
| SCHEMBL5759317 | 0.86 | TP53 (0.52) | PDE10ARXFP1TP53LMNAMAPT | |
| SCHEMBL5759479 | 0.86 | PDE10A (0.48) | PDE10ARXFP1TP53ELANECNR2 | |
| SCHEMBL5758809 | 0.85 | PDE10A (0.45) | PDE10ARXFP1TP53LMNAMAPT | |
| SCHEMBL5758764 | 0.85 | CNR2 (0.48) | PDE10AMAPTKMT2AKLKB1APEX1 | |
| SCHEMBL5758891 | 0.85 | PDE10A (0.50) | PDE10AKMT2AKLKB1ELANEAPEX1 | |
| SCHEMBL27624377 | 0.84 | PDE10A (0.45) | PDE10ARXFP1TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043924-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |