Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757751 | 0.96 | HPGD (0.52) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5755694 | 0.93 | HPGD (0.44) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5757140 | 0.87 | HPGD (0.54) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL27624384 | 0.86 | KLKB1 (0.49) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5755639 | 0.85 | CYP1A2 (0.48) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5755268 | 0.83 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5757755 | 0.81 | CA1 (0.52) | ALDH1A1KDM4E | |
| SCHEMBL5758015 | 0.80 | KDM4E (0.51) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5757758 | 0.80 | TP53 (0.61) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL6212966 | 0.79 | RXFP1 (0.50) | MAPTLMNAALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043924-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |