Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 18/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 18/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219138 | 0.89 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6296632 | 0.86 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6782399 | 0.85 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6272493 | 0.84 | ADRA1A (0.67) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL8596943 | 0.82 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL8592793 | 0.82 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785443 | 0.81 | ADRA1A (0.65) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6793226 | 0.81 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7236022 | 0.79 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6269746 | 0.79 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |