Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.85 |
| ▸ | INSR | P06213 | 6/20 | 0.73 |
| ▸ | LYN | P07948 | 5/20 | 0.73 |
| ▸ | LCK | P06239 | 5/20 | 0.73 |
| ▸ | KDR | P35968 | 5/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.73 |
| ▸ | FLT3 | P36888 | 4/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.73 |
| ▸ | FLT4 | P35916 | 3/20 | 0.73 |
| ▸ | CSF1R | P07333 | 3/20 | 0.73 |
| ▸ | BLK | P51451 | 3/20 | 0.73 |
| ▸ | AURKA | O14965 | 2/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.73 |
| ▸ | MARK3 | P27448 | 2/20 | 0.73 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.73 |
| ▸ | NEK2 | P51955 | 2/20 | 0.73 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.73 |
| ▸ | STK3 | Q13188 | 2/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11345478 | 0.92 | IGF1R (1.00) | IGF1RINSRLYNLCKKDR | |
| Dimethylcarbate SCHEMBL6217753 | 0.92 | IGF1R (0.85) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL11345526 | 0.90 | IGF1R (1.00) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL5936232 | 0.89 | IGF1R (0.72) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL5936230 | 0.89 | IGF1R (0.72) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL1983408 | 0.88 | IGF1R (0.75) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL1986584 | 0.88 | IGF1R (0.75) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL1983409 | 0.88 | IGF1R (0.75) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL5936295 | 0.87 | IGF1R (0.76) | IGF1RINSRLYNLCKKDR | |
| SCHEMBL11350290 | 0.87 | IGF1R (0.77) | IGF1RINSRLYNLCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390369-B1 | 4-AMINO-5-PHENYL-7-CYCLOBUTYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2005-11-09 | — | — | EP | claimed |