Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215237 | 0.85 | ACHE (0.54) | ACHENPC1RAB9ACHRM2CHRM3 | |
| SCHEMBL6421231 | 0.84 | ACHE (0.56) | ACHENPC1RAB9ACHRM2CHRM3 | |
| SCHEMBL6346963 | 0.83 | ACHE (0.52) | ACHECHRM3KMT2AMEN1POLB | |
| SCHEMBL6370380 | 0.83 | ACHE (0.57) | ACHENPC1RAB9ACHRM2CHRM3 | |
| SCHEMBL6354271 | 0.82 | ACHE (0.52) | ACHECHRM3KMT2AMEN1POLB | |
| SCHEMBL6370819 | 0.82 | ACHE (0.52) | ACHENPC1RAB9ACHRM2CHRM3 | |
| SCHEMBL6219313 | 0.81 | ACHE (0.51) | ACHECHRM2CHRM3KMT2AMEN1 | |
| SCHEMBL4842118 | 0.81 | ACHE (0.66) | ACHECHRM2CHRM3KMT2AMEN1 | |
| SCHEMBL6216961 | 0.80 | ACHE (0.52) | ACHECHRM2CHRM3KMT2AMEN1 | |
| SCHEMBL6216563 | 0.80 | ACHE (0.58) | ACHECHRM2CHRM3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192132-B1 | SERINE PROTEASE INHIBITORS | LILLY CO ELI (US) | 2005-09-07 | — | — | EP | disclosed |
| US-6855715-B1 | Serine protease inhibitors | ELI LILLY AND COMPANY (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1192132-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076971-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |