Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794754 | 0.84 | PTK2 (0.59) | PTK2METCYP1A2GAARAB9A | |
| SCHEMBL24969499 | 0.81 | KMT2A (0.60) | PTK2METCYP1A2GAACDK8 | |
| SCHEMBL9646713 | 0.81 | PTK2 (0.56) | PTK2METCYP1A2GAACDK8 | |
| SCHEMBL26802297 | 0.81 | PTK2 (0.56) | PTK2METCYP1A2GAACDK8 | |
| SCHEMBL28286246 | 0.80 | PTK2 (0.54) | PTK2METCYP1A2GAACDK8 | |
| SCHEMBL12935883 | 0.80 | PTK2 (0.54) | PTK2METCYP1A2GAAKMT2A | |
| SCHEMBL9649264 | 0.80 | PTK2 (0.58) | PTK2METCYP1A2GAACDK8 | |
| SCHEMBL15762386 | 0.80 | PTK2 (0.54) | PTK2METCYP1A2GAACDK8 | |
| SCHEMBL6219934 | 0.80 | RAB9A (0.46) | RAB9ANPC1MAPTDEGS1L3MBTL1 | |
| SCHEMBL25045493 | 0.79 | PTK2 (0.53) | PTK2METCYP1A2GAACDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517895-A1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000814-A1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-12-31 | — | — | WO | disclosed |