Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.45 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920191 | 0.90 | DHODH (0.58) | DHODHESR2IKBKBHDAC3HDAC1 | |
| SCHEMBL441953 | 0.87 | DHODH (0.65) | DHODHESR2PARP1PTPN1PTPN2 | |
| SCHEMBL3920472 | 0.86 | CETP (0.55) | DHODHESR2IKBKBHDAC3HDAC1 | |
| SCHEMBL121395 | 0.85 | DHODH (0.78) | DHODHESR2HDAC6PTPN1PTPN2 | |
| SCHEMBL505539 | 0.84 | DHODH (1.00) | DHODHESR2PTPN1HTR3AESR1 | |
| SCHEMBL121400 | 0.84 | DHODH (0.94) | DHODHESR2HTR3AESR1 | |
| SCHEMBL5109570 | 0.83 | DHODH (0.76) | DHODHESR2HDAC6HTR3APOLB | |
| SCHEMBL120313 | 0.82 | DHODH (0.78) | DHODHESR2IKBKBHTR3APOLB | |
| SCHEMBL18951247 | 0.80 | PTPN2 (0.45) | DHODHESR2IKBKBHDAC3HDAC1 | |
| SCHEMBL7376189 | 0.80 | PTPN5 (0.57) | DHODHHDAC6PTPN1PTPN2PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585726-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063155-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |