Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 13/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 11/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 11/20 | 0.57 |
| ▸ | HSPE1 | P61604 | 11/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 10/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441953 | 0.80 | DHODH (0.65) | PTPN5PTPN1PTPN2DHODHMEN1 | |
| SCHEMBL6216739 | 0.80 | DHODH (0.72) | PTPN5PTPN1HSPD1HSPE1PTPN2 | |
| SCHEMBL7377092 | 0.76 | CCR9 (0.51) | PTPN1HSPD1HSPE1PTPN2DHODH | |
| SCHEMBL5373826 | 0.75 | PTPN1 (0.74) | PTPN5PTPN1HSPD1HSPE1PTPN2 | |
| SCHEMBL9997380 | 0.74 | PFKFB3 (0.64) | MEN1GAAKMT2AMCL1ACLY | |
| SCHEMBL396095 | 0.73 | AKR1C3 (0.62) | MEN1GAAKMT2AHDAC6 | |
| SCHEMBL5373250 | 0.73 | POLB (0.63) | MEN1KMT2AMCL1ACLY | |
| SCHEMBL7372415 | 0.72 | PTPN2 (0.56) | PTPN5PTPN1HSPD1HSPE1PTPN2 | |
| SCHEMBL5368419 | 0.72 | POLB (0.66) | PTPN5MEN1KMT2AMCL1HDAC6 | |
| SCHEMBL4253314 | 0.72 | PTPN1 (0.75) | PTPN5PTPN1HSPD1HSPE1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | claimed |
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | disclosed |