Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 19/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 18/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482596 | 0.89 | OPRM1 (0.75) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL6215016 | 0.86 | OPRM1 (0.77) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL6476563 | 0.85 | OPRL1 (0.72) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL7091964 | 0.84 | OPRL1 (0.74) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL7094987 | 0.84 | OPRL1 (0.74) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL6215206 | 0.83 | OPRL1 (0.81) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL6475560 | 0.83 | OPRL1 (0.75) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL6483134 | 0.83 | OPRL1 (0.72) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL6475855 | 0.81 | OPRL1 (0.78) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL7095226 | 0.81 | OPRM1 (0.71) | OPRL1OPRM1OPRK1OPRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122257-B1 | Benzimidazole compounds as ORL1-receptor agonists | PFIZER (US) | 2005-10-12 | — | — | EP | disclosed |
| US-6861425-B2 | Benzimidazole compounds as ORL1-receptor agonists | PFIZER, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20020049212-A1 | Benzimidazole compounds as ORL1-receptor agonists | PFIZER PRODUCTS INC. | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049212-A1 | Benzimidazole compounds as ORL1-receptor agonists | OPRL1, ORMDL3, OGFRL1 | OPRL1 1/4885OPRM1 4/4885OPRK1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.