⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14611549 | 0.81 | — | — | |
| SCHEMBL30060684 | 0.77 | — | — | |
| SCHEMBL2033970 | 0.77 | — | — | |
| SCHEMBL8257576 | 0.77 | — | — | |
| SCHEMBL2414672 | 0.75 | — | — | |
| SCHEMBL10255501 | 0.75 | — | — | |
| SCHEMBL4883086 | 0.75 | — | — | |
| SCHEMBL841270 | 0.75 | — | — | |
| SCHEMBL29625025 | 0.75 | — | — | |
| SCHEMBL8919061 | 0.73 | CDK2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1307179-C | pyrimidine derivatives for inhibiting cell proliferation | ASTRAZENECA AB (SE) | 2007-03-28 | — | — | CN | disclosed |
| EP-1362050-B1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | ASTRAZENECA AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| US-6844341-B2 | Pyrimidine derivatives for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2005-01-18 | — | — | US | disclosed |
| CN-1524081-A | Pyrimidine derivatives for inhibition of cell proliferation | — | 2004-08-25 | — | — | CN | disclosed |
| US-20040097506-A1 | Pyrimidine derivatives for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2004-05-20 | — | — | US | disclosed |
| EP-1362050-A1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | AstraZeneca AB (SE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066481-A1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | ASTRAZENECA AB (SE) | 2002-08-29 | — | — | WO | disclosed |