Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | FRK | P42685 | 1/20 | 0.55 |
| ▸ | BLK | P51451 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696752 | 1.00 | KDR (0.55) | KDRRETDYRK3ROCK2MAP4K4 | |
| SCHEMBL2635645 | 0.81 | RAB9A (0.54) | KDRRETROCK1EGFRTP53 | |
| SCHEMBL4823033 | 0.80 | KDR (0.52) | KDRRETDYRK3ROCK2MAP4K4 | |
| SCHEMBL1335513 | 0.78 | KDR (0.49) | KDRRETDYRK3ROCK2MAP4K4 | |
| SCHEMBL1748096 | 0.76 | NPC1 (0.43) | KDRRETEGFRTP53MAPT | |
| SCHEMBL3817585 | 0.76 | KCNH2 (0.38) | KDRRETDYRK3ROCK2MAP4K4 | |
| SCHEMBL5803349 | 0.74 | NPC1 (0.69) | TP53MAPTNPC1RAB9AMEN1 | |
| SCHEMBL3817655 | 0.73 | NPC1 (0.49) | KDRRETEGFRTP53MAPT | |
| SCHEMBL14268386 | 0.73 | KDR (0.55) | KDRRETDYRK3ROCK2MAP4K4 | |
| SCHEMBL1334184 | 0.72 | KDR (0.62) | KDRRETDYRK3ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379528-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH (DE) | 2005-12-07 | — | — | EP | disclosed |
| EP-1379528-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GmbH (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076986-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-03 | — | — | WO | disclosed |