Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17242039 | 0.83 | MEN1 (0.39) | MEN1KMT2AIDO1MAPTSMN1; SMN2 | |
| SCHEMBL12109857 | 0.81 | MEN1 (0.51) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL5537888 | 0.81 | MEN1 (0.51) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL11834129 | 0.81 | MEN1 (0.51) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL7469260 | 0.80 | ALDH1A1 (0.59) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL1771923 | 0.80 | MEN1 (0.50) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL201830 | 0.80 | ALDH1A1 (0.61) | MEN1KMT2AIDO1MAPTSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL28528068 | 0.80 | MEN1 (0.50) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL5537891 | 0.80 | MEN1 (0.54) | MEN1KMT2AIDO1GABRA1GABRB2 | |
| SCHEMBL2139684 | 0.80 | MAPT (0.62) | MEN1KMT2AIDO1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585726-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063155-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |