SCHEMBL6220735

SCHEMBL6220735

Nc1cc2ccnc(N)c2cc1CN1CC[C@H](NS(=O)(=O)c2cc3ncccc3s2)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 1.00
F2 P00734 10/20 0.63
PROC P04070 8/20 0.63
PLG P00747 7/20 0.63
PRSS1 P07477 6/20 0.63
PLAT P00750 5/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12589596 0.88 F10 (1.00) F10F2PROCPLGPRSS1
SCHEMBL7540125 0.88 F10 (1.00) F10F2PROCPLGPRSS1
Trifluoroacetic Acid SCHEMBL7538088 0.82 F10 (0.88) F10F2PROCPLGPRSS1
Trifluoroacetic Acid SCHEMBL7545759 0.82 F10 (0.88) F10F2PROCPLGPRSS1
SCHEMBL7536954 0.82 F10 (0.80) F10F2PROCPLGPRSS1
Trifluoroacetic Acid SCHEMBL7537120 0.80 F10 (0.66) F10F2PROCPLGPRSS1
Trifluoroacetic Acid SCHEMBL7219160 0.80 F10 (0.66) F10F2PROCPLGPRSS1
Trifluoroacetic Acid SCHEMBL7449959 0.80 F10 (0.66) F10F2PROCPLGPRSS1
SCHEMBL7214244 0.79 F10 (0.65) F10F2PROCPLGPRSS1
SCHEMBL7539523 0.79 F10 (0.83) F10F2PROCPLGPRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086099-B1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMA INC (US) 2005-09-28 EP claimed
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMACEUTICALS PRODUCTS INC. 2002-01-31 US claimed
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMACEUTICALS PRODUCTS INC. 2002-01-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds STS, ARSA, F12 F10 20/4885F2 11/4885PROC 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.