Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.67 |
| ▸ | PI4KA | P42356 | 2/20 | 0.67 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.67 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.67 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.67 |
| ▸ | GAPDH | P04406 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22559755 | 0.92 | ADORA3 (0.67) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL6849225 | 0.92 | ADORA3 (0.67) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL6222975 | 0.92 | ADORA3 (0.67) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL23928781 | 0.92 | ADORA3 (0.72) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28991005 | 0.92 | ADORA3 (0.72) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30274521 | 0.92 | ADORA3 (0.72) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28991009 | 0.92 | ADORA3 (0.72) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL24872346 | 0.91 | ADORA1 (0.66) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL4456275 | 0.91 | ADORA1 (0.66) | ADORA3ADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL25284572 | 0.91 | ADORA1 (0.66) | ADORA3ADORA1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716604-B1 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2005-03-16 | — | — | EP | disclosed |
| US-6265558-B1 | COMPOUND OF LINKED NUCLEOSIDES HAVING THIOL GROUP ATTATCHED AT 5-PYRIMIDINE OR 2-, 6-, OR 8-PURINE POSITIONS; ATTACHMENT REPORTER MOLECULES, REPORTER ENZYMES, STEROIDS, LIPOPHILIC MOLECULES, PEPTIDES, PROTEINS AND OTHER GROUPS | ISIS PHARMACEUTICALS, INC. | 2001-07-24 | — | — | US | disclosed |
| US-6114513-A | MEDICAL DIAGNOSIS; TRANSFER ACROSS CELL MEMBRANES | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| US-5578718-A | Thiol-derivatized nucleosides | ISIS PHARMACEUTICALS, INC. (US) | 1996-11-26 | — | — | US | disclosed |